"Every amino acid matters, but people matter more" - the work of C. David Allis rewrote the textbook on how gene expression is regulated, but to everyone lucky to have known him personally, his impact extended far beyond fundamental discoveries. Dave's optimism and infectious excitement for science paired uniquely with a humble and gentle personality. Seemingly random souvenirs and photos of family and lab members past and present (the "lab family" term was used often) covered his office floor to ceiling, and brought more joy to him than his (well deserved) Nike of Samothrace. Colors of chromatin shine less brightly today, but his legacy will live on.
New Lab Member:
Cameron joins the lab! It takes special courage to be the first employee - when scientific challenges are overshadowed by organizational ones. Welcome!
A fantastic story by Yadira Soto-Feliciano, Francisco Sanchez-Rivera, and many great collaborators in the Allis, Lowe and Armstrong labs is finally out in Cancer Discovery! One step closer to understanding the (non)redundancies of Mixed Lineage Leukemia methyltransferases, and how they can be leveraged in practical therapies for AML. Congratulations to Yadira and all!
All* cells in human body carry same "blueprint" of genomic DNA, yet their phenotypes and functions are remarkably different - suggesting that genes are differentially regulated.
*exclusions apply, as always
Moreover, ~3.2 billion base pairs of DNA in every human cell* are folded into a nucleus - usually only a few microns in diameter - while preserving precise regulation of individual gene function. We aim to understand how this extraordinary level of compaction is achieved, and how, when misregulated, it drives human disease - from malignancy to developmental disorders.
We study gene regulation by H1 linker histones - small, dynamic proteins that contribute to both compaction of chromatin fiber (a complex of DNA and many nuclear proteins), and regulation of gene expression.
Alexey A. Soshnev
(...and your face could be here!)
Alexey A. Soshnev
(210) 458-7950 (office)
(210) 458-7951 (lab)
Department of Neuroscience, Developmental and Regenerative Biology
#sciart - some hits and a few misses we are still proud of:
This could have been a cover for our Cancer Cell review on epigenetic misregulation in glioma. It was not selected.
This could have been a cover for Ho and Treisman from NYU/Skirball. It was not selected.
This could have been a cover for Finkin et al from Nussenzweig Lab at Rockefeller. It was not selected.
This could have been a cover for Shimada et al. from Roeder Lab at Rockefeller. It was not selected.
This is not strictly a cover, but still a cool image that ended up printed in Medicine Iowa journal.