What we do:
All* cells in human body carry same "blueprint" of genomic DNA, yet their phenotypes and functions are remarkably different - suggesting that genes are differentially regulated.
*exclusions apply, as always
Moreover, ~3.2 billion base pairs of DNA in every human cell* are folded into a nucleus - usually only a few microns in diameter - while preserving precise regulation of individual gene function. We aim to understand how this extraordinary level of compaction is achieved, and how, when misregulated, it drives human disease - from malignancy to developmental disorders.
We study gene regulation by H1 linker histones - small, dynamic proteins that contribute to both compaction of chromatin fiber (a complex of DNA and many nuclear proteins), and regulation of gene expression.
Who we are:
Alexey A. Soshnev
Cam wins best poster award at PSU Summer Symposium!
Cameron presented a developing story on the role of Polycomb Repressive Complex 2 in embryonic stem cells - a tour-de-force project encompassing gene editing, imaging, ChIP- and RNA-Seq, all together suggetsing that both loss and gain of PRC2-dependent histone H3 lysine 27 methylation drives functionally similar transcriptional and developmental outcomes. This is the first trainee award in our lab - congratulations!
We got a grant:
Our pilot project to develop in vivo single-molecule imaging platform for wild type and mutant linker histones is now funded through American Cancer Society and Mays Cancer Center at UT Health! Stay tuned for more to come!
We are growing!
Dustin Fetch and Amina Jumamyradova have joined the lab!
"A de novo sequence variant in Barrier-to-Autointegration Factor Is associated with dominant motor neuronopathy" - Last month, we helped the Geyer and Zinn-Justin labs run a few Western blots to document histone modification changes associated with a unique point mutation in Barrier-to-Autoinregration Factor (BAF) protein. The story is now available online! Congratulations to all who contributed to this collaboration!
"Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells" - What started as a number of puzzling observations about how lipid supplements affect pluripotency circuit in culture, is now hot off the press at Protein & Cell - highlighting how deeply metabolic regulation is connected to genome integrity, epigenetic mechanisms, and whole organism development. Congratulations to all authors, and special kudos to Liangwen and Duancheng!
"Every amino acid matters, but people matter more" - the work of C. David Allis rewrote the textbook on how gene expression is regulated, but to everyone lucky to have known him personally, his impact extended far beyond fundamental discoveries. Dave's optimism and infectious excitement for science paired uniquely with a humble and gentle personality. Seemingly random souvenirs and photos of family and lab members past and present (the "lab family" term was used often) covered his office floor to ceiling, and brought more joy to him than his (well deserved) Nike of Samothrace. Colors of chromatin shine less brightly today, but his legacy will live on.
New Lab Member:
Cameron joins the lab! It takes special courage to be the first employee - when scientific challenges are overshadowed by organizational ones. Welcome!
A fantastic story by Yadira Soto-Feliciano, Francisco Sanchez-Rivera, and many great collaborators in the Allis, Lowe and Armstrong labs is finally out in Cancer Discovery! One step closer to understanding the (non)redundancies of Mixed Lineage Leukemia methyltransferases, and how they can be leveraged in practical therapies for AML. Congratulations to Yadira and all!
#sciart - some hits and a few misses we are still proud of:
This could have been a cover for our Cancer Cell review on epigenetic misregulation in glioma. It was not selected.
This could have been a cover for Ho and Treisman from NYU/Skirball. It was not selected.
This could have been a cover for Finkin et al from Nussenzweig Lab at Rockefeller. It was not selected.
This could have been a cover for Shimada et al. from Roeder Lab at Rockefeller. It was not selected.
This is not strictly a cover, but still a cool image that ended up printed in Medicine Iowa journal.
Alexey A. Soshnev
(210) 458-7950 (office)
(210) 458-7951 (lab)
Department of Neuroscience, Developmental and Regenerative Biology